Enhancing health information literacy is an effective approach to improving the health literacy and well-being of rural residents, and achieving this improvement in health information literacy requires various health science popularization services provided by libraries. Library science popularization services have a solid legal and theoretical basis, and health services represent a new frontier in the development of library science popularization services in the new era. In the context of rural revitalization, libraries are faced with challenges such as the diversification of rural residents' health information access channels, the growing digital divide in health information, and the increasing internal demand for health information services. To address these challenges, libraries need to promote health information dissemination services from multiple dimensions, establish a team of health information librarians, and build collaborative mechanisms with various stakeholders to enhance the effectiveness and quality of library-based health science popularization services for rural residents.