Scientific research intellectualization is continuously promoting the transformation and upgrading of the scientific research paradigm. The knowledge service by integrating smart robots has emerged as a promising foundation for supporting the high-quality development of national science and technology innovation in the new era. By employing literature research and case analysis, this study analyzes the development of scientific research intellectualization and its contribution to the formation of knowledge service by smart robot. Additionally, it explores the connotation process and typical pattern of knowledge service by integrating smart robot from the perspective of scientific research intellectualization. The suggests are concluded, including improving the machine representation and correlation fusion of data resources, establishing service guaranteeing and coordination mechanisms of human-AI collaboration, addressing privacy and security concerns, and optimizing the process and calculation efficiency in knowledge computation, which can promote high-quality development and enhance the effectiveness of scientific research.