Data, information, and knowledge are the key elements of crisis management, as well as the basis and important support for emergency management decision-making. The advantages of information resources should be fully used to solve the problem of "isolated data island ", and coordinately respond to and manage major public health emergencies. Based on the existing information fusion research, this paper draws on the Dasarathy and the JDL information fusion model to construct a multi-source heterogeneous emergency information fusion model. The model is based on the integration of multi-source heterogeneous emergency information, and aims to serve emergency management and emergency decision-making needs, and achieves the overall and systematic integration of the four key elements of information entities, information sources, information fusion technology and information environment. It can provide information services for risk monitoring, public opinion management, emergency response and decision-making of public health emergencies, and further reduce various losses caused by major public health emergencies.