The outbreak of COVID-19 epidemic has brought great impact as well as new challenges to the cultivation system of information literacy in our country. Combined with the actual performance of the information literacy of various subjects in COVID-19, the paper expounds the challenges and opportunities brought by COVID-19 epidemic from three aspects: teaching information literacy, media information literacy and life information literacy. At last, the paper gives some thoughts on the development of information literacy training in the post epidemic period from the construction of learning society, information literacy education, the implementation of special action, and the role of the library.