Emergency information service system is an important part and strong support of emergency management, in which science and technology scientific information service is the most important. The purpose of this paper is to study and practice the emergency integrated knowledge consulting service system and service mode to deal with major public health emergency，that is COVID-19. This paper analyzes the information characteristics and demand of this major public health event, and summarizes the research progress of emergency information service. Based on this article establishes an integrated emergency knowledge consulting service system for containing COVID-19, which includes the "Integrated Information Platform for Containing COVID-19" guided by the concept of big data information service，as well as the "Science Decision-making Advisory Service System" guided by the integrated "professional, computational, methodological, strategic and policy" strategy research paradigm and advisory service concept. It has also carried out a full range of science and technology information knowledge services and strategic decision-making consulting services, achieved good results in knowledge consulting services, and fully played the role of the mission of professional science and technology think tanks.