The flow of information driven by emerging technologies is impacting traditional education at an unprecedented rate, and the evidence-based educational practice guided by empirical research provides more scientific and rigorous research concept, framework and methods for the efficient information flow. The paper mainly explores the mode, the process and the effect of information flow of evidence-based education. The study concludes that the scientific advancement of disciplines and the deep integration of education and information have contributed to the development of evidence-based education。The information flow of evidence-based education has created conditions for the deep learning from the sources of evidence, evidence-based framework and evidence-based methods. Evidence-based education provides direction for the information flow, and the information flow of evidence-based education has triggered many effects, such as the rethinking of "understanding", creating open issues, and changing educational structures.