As the significant determinate and predictor of health, health literacy draws much attention globally. China started the work stream on developing the general health literacy very early. However, some problems are still existing such as the unequal development level of health literacy between urban and rural areas, and uneven recognition level of health problems among different groups. This study is based on the literature review and posits several hypotheses on the health literacy distribution between urban-rural areas, and the heterogeneous effects of different information intermediaries on health literacy improvement respectively. A set of empirical models are distributed to attest the hypotheses. Then the cross-sectional data from China Health and Nutrition Survey(CHNS) of the year 2015 is employed and the least square regression is used to estimate the empirical models. Several conclusions are drawn from the results: The difference of health literacy exists significantly between urban and rural areas.Although health information acquisitions have general positive effects on health literacy, the ICT source contribute more than other intermediaries.The ICT source contributes more positive effects on health literacy in rural settings compared with that in urban environment.