Since the beginning of the 19th century, the science paradigm has undergone a series of development and evolution. It is characterized by the developments from closed laboratory cooperation to large-scale collaboration, from single-disciplinary research to interdisciplinary research and from interest-oriented pattern to problem-oriented pattern. The trends of the science paradigm towards openness and integration have been largely promoted by the development of computer networks and information technology. Based on its development process and existing literature, the paper divides the development process of the science paradigm into three stages——closed-workshop style, multi-collaborative style and open-integrated style. Then it analyzes the organizational mode and practical significance of the current open-integrated science paradigm. Finally, based on the research status and development requirements, the paper proposes future research directions in this field.