The paper chooses the information-technology-human dimension to analyzes the influence of the big data on the information science from three aspects and to explain the relationship between the goal of big data application of extracting knowledge from data and the goal of the information science of establishing the association of human and knowledge. Based on the case analysis of the NIH's Big Data to Knowledge (BD2K) initiative, big data coping strategies of the information science is proposed, such as information-technology-human、data ecosystem construction and data literacy promotion.