With the rapid development of globalization and informatization, the cyberspace environment is becoming increasingly complex and changeable. The national information security management is facing new opportunities and challenges in the digital age. Grasping the key issues of the national information security management in the new era is of great benefit to strengthen Chinese information security protection. Based on the background of digital economy and society, this paper explained four strategic development directions: Data sovereignty security in cross-border data flow governance, citizen privacy and public data security in data opening, software and hardware equipment security related to key information technology research and development, and information security personnel training. This paper analyzed the hidden dangers of information security in various development directions, and put forward some research suggestions on information security management for academic circles.