以新安全格局保障新发展格局的时代背景下，提升重大突发事件的响应能力成为极具现实意义的实践课题，有助于加快推进应急管理体系和能力现代化。文章首先全面分析重大突发事件科学响应的现实问题，于理论、体系及能力三个方面提出优化方向；其次以重大突发事件的情报感知为流程指导，以大模型智能体为技术赋能，探索情报响应的概念内涵及体系建设思路，提出集综合任务指挥层、应急资源管理层、双重响应处理层及主体协同联动层为一体的重大突发事件情报响应体系；最后回应聚焦的现实问题，提出重大突发事件的响应策略。我国面临的安全挑战和应急管理困境，需要进行体系化应对，而体系应对考验的则是体系能力。大模型智能体赋能的重大突发事件情报响应体系，是开展情报分析与管理活动有机融合的可行思路。

In the context of safeguarding the new development paradigm with a new security landscape, enhancing the response capabilities for major emergencies has become a highly practical research topic, which is conducive to accelerating the modernization of emergency management systems and capabilities. Firstly, this research comprehensively analyzes the current issues in scientific response for major emergencies and proposes optimization directions in three aspects: theory, system, and capability. Secondly, based on intelligence awareness as a process guide and LLM-based Agents as a technology enabler, this research explores the conceptual connotation and system construction approach of intelligence response, proposes an intelligence response system that integrates a comprehensive task command level, emergency resource management level, dual-response deal level, and multi-agent collaboration and linkage level. Lastly, it presents response strategies for major emergencies, after addressing the practical issues highlighted in this paper. The security challenges and emergency management dilemmas faced by China necessitate a systematic approach, which in turn tests the capabilities of the system. Intelligence response system for major emergencies, empowered by LLM-based Agents, represents a feasible way to integrate intelligence analysis and management activities organically.