信息和知识贯穿于重大突发疫情生命周期各阶段风险研判与决策过程的始终，不但是其基础和重要支撑，更在风险研判与决策过程中发挥着驱动作用。重大突发疫情风险研判与决策柔性协同机制以信息聚合机制、知识发现平台为关键性驱动力量，以中心式矩阵型决策主体组织架构为核心构件，涵盖事件发展全过程、具有一定的柔性、能充分调动各方资源、实现多部门与多主体协同高效配合，可为突发重大公共卫生事件风险全面防控与有效应对、防范化解重大风险提供支撑。

Information and knowledge，which are not only the foundation and important support, but also  a driving force in the process of risk assessment and decision-making, run through all stages of risk assessment and decision-making in the life cycle of major epidemics. Based on the characteristics of risk assessment and decision-making in major epidemics and related research, this paper explores the basic framework of collaborative mechanism of risk assessment and decision-making in major outbreaks, information aggregation mechanism and knowledge discovery platform, and constructs a flexible collaborative mechanism of risk assessment and decision-making of major epidemics. The mechanism takes the information aggregation mechanism and knowledge discovery platform as the key driving force, and the central matrix decision-making body organizational structure as the core component. It covers the whole process of event development, has certain flexibility, can fully mobilize the resources of all parties, and can achieve multi-sector and multi-agent collaborative and efficient cooperation. It provides support for the comprehensive prevention and control of the risk of major epidemics, effective response, prevention and resolution of major risks.