：“双一流”建设不仅是国家高等教育战略，也应带动区域科技创新与发展。文章从“双一流”建设学科与区域产业发展互动的角度，以上海市为例，将上海市“全球科创中心”建设中的信息技术、生物医药、装备制造三大重点领域与该市在国家“双一流”建设中的相关学科进行关联分析。基于Web of Science数据库2012-2016年上海“双一流”建设学科在三大领域的基础研究论文数据，从产出支撑水平、学科特色优势、企业协作倾向三个方面进行分析。研究发现：上海市“双一流”建设学科发展速度低于该学科整体，其高校与企业合作比重也存在提升空间；上海市生物医药与装备制造领域的“双一流”建设学科对区域企业创新均具有一定引领作用，但信息技术领域“双一流”学科科研支撑需进一步提升与加强。

The "Double First-class" disciplines are not only related to the development strategy of the national colleges and universities, but also to the regional science and technology innovation and development from the meso level. This paper developed from the combination of the development of "Double First-class" disciplines and regional innovation by taking Shanghai as sample city and using the " Global Innovation Center" in the construction of information technology, bio medicine, equipment manufacturing and the related areas in national "Double First-class" strategy. Taking Web of Science database as the data source and 2012-2016 as the time window, this study studies the trend analysis of output level, discipline superiority, and enterprise collaboration innovation structure, and forms a comprehensive analysis of development level in "Double First-class" disciplines in key industrial areas of Shanghai. It found that the growth rate of publications and  of "Double First-class" disciplines is lower than that of overall in Shanghai, and the proportion of its enterprise collaboration also exists the promotion room. Bio medicine and equipment manufacturing all have the characteristics of "Double First-class" leading disciplines while the disciplines of information technology needs further upgrading and strengthening.