：自19世纪初以来，科学研究组织范式经历了一系列发展演变过程。具体表现为由封闭的实验室合作向开放的规模化合作发展，由单学科研究向跨学科研究发展，由兴趣导向式向问题导向式发展，其中计算机网络和信息技术的发展极大地推动了现代科学研究组织范式的开放集成化发展趋势。依据其发展历程并参照已有文献，文章将科学研究组织范式的发展分为封闭协作式、多元合作式和开放集成式三个阶段，着重分析了当前开放集成式科学研究组织范式的组织模式及其现实意义，并根据研究现状和发展需求提出了该领域今后的研究方向。

Since the beginning of the 19th century, the science paradigm has undergone a series of development and evolution. It is characterized by the developments from closed laboratory cooperation to large-scale collaboration, from single-disciplinary research to interdisciplinary research and from interest-oriented pattern to problem-oriented pattern. The trends of the science paradigm towards openness and integration have been largely promoted by the development of computer networks and information technology. Based on its development process and existing literature, the paper divides the development process of the science paradigm into three stages——closed-workshop style, multi-collaborative style and open-integrated style. Then it analyzes the organizational mode and practical significance of the current open-integrated science paradigm. Finally, based on the research status and development requirements, the paper proposes future research directions in this field.